3KSQ: Discovery of C-Imidazole Azaheptapyridine FPT Inhibitors

PDB ID: 3KSQDownload
MMDB ID: 79644
PDB Deposition Date: 2009/11/23
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 3KSQ: dimeric; determined by author and by software (PISA)
Molecular Components in 3KSQ
Label Count Molecule
Proteins (2 molecules)
1
Farnesyltransferase, Caax Box, Alpha
(Gene symbol: Fnta)
Molecule annotation
1
Protein Farnesyltransferase Subunit Beta
(Gene symbol: Fntb)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
MAGNESIUM IONMAGNESIUM ION
2
1
ZINC IONZINC ION
3
1
FARNESYL DIPHOSPHATEFARNESYL DIPHOSPHATE
4
1
tert-butyl 4-{(11S)-8-chloro-6-[(R)-hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl}piperazine-1-carboxylatetert-butyl 4-{(11S)-8-chloro-6-[(R)-hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl}piperazine-1-carboxylate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303