3KR8: Human Tankyrase 2 - Catalytic Parp Domain In Complex With An Inhibitor Xav939

Citation:
Abstract
We report two crystal structures of the PARP domain of human tankyrase-2 (TNKS2). Tankyrases are involved in fundamental cellular processes such as telomere homeostasis and Wnt signaling. The complex of TNKS2 with the potent inhibitor XAV939 provides insights into the molecular basis of the strong interaction and suggests routes for further development of tankyrase inhibitors.
PDB ID: 3KR8Download
MMDB ID: 78796
PDB Deposition Date: 2009/11/18
Updated in MMDB: 2009/12
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 3KR8: monomeric; determined by author and by software (PISA)
Molecular Components in 3KR8
Label Count Molecule
Protein (1 molecule)
1
Tankyrase-2(Gene symbol: TNKS2)
Molecule annotation
Chemicals (5 molecules)
1
1
2
1
3
2
4
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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