National Center for
3KR8: Human Tankyrase 2 - Catalytic Parp Domain In Complex With An Inhibitor Xav939
J. Med. Chem. (2010) 53 p.5352-5355
We report two crystal structures of the PARP domain of human tankyrase-2 (TNKS2). Tankyrases are involved in fundamental cellular processes such as telomere homeostasis and Wnt signaling. The complex of TNKS2 with the potent inhibitor XAV939 provides insights into the molecular basis of the strong interaction and suggests routes for further development of tankyrase inhibitors.