3KME: Crystal structure of catalytic domain of TACE with phenyl-pyrrolidinyl-tartrate inhibitor

PDB ID: 3KMEDownload
MMDB ID: 78954
PDB Deposition Date: 2009/11/10
Updated in MMDB: 2009/12
Experimental Method:
x-ray diffraction
Resolution: 1.85  Å
Source Organism:
Similar Structures:
Biological Unit for 3KME: monomeric; determined by author and by software (PISA)
Molecular Components in 3KME
Label Count Molecule
Protein (1 molecule)
1
Tnf-alpha-converting Enzyme
(Gene symbol: ADAM17)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
ZINC IONZINC ION
2
1
N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamideN-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide
3
1
ISOPROPYL ALCOHOLISOPROPYL ALCOHOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303