3KB6: Crystal structure of D-Lactate dehydrogenase from aquifex aeolicus complexed with NAD and Lactic acid

Citation:
Abstract
The crystal structure of D-lactate dehydrogenase from Aquifex aeolicus (aq_727) was determined to 2.12 A resolution in space group P2(1)2(1)2(1), with unit-cell parameters a = 90.94, b = 94.43, c = 188.85 A. The structure was solved by molecular replacement using the coenzyme-binding domain of Lactobacillus helveticus D-lactate dehydrogenase and contained two homodimers in the asymmetric unit. Each subunit of the homodimer was found to be in a ;closed' conformation with the NADH cofactor bound to the coenzyme-binding domain and with a lactate (or pyruvate) molecule bound at the interdomain active-site cleft.
PDB ID: 3KB6Download
MMDB ID: 78067
PDB Deposition Date: 2009/10/20
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 2.12  Å
Source Organism:
Similar Structures:
Biological Unit for 3KB6: tetrameric; determined by author and by software (PISA)
Molecular Components in 3KB6
Label Count Molecule
Proteins (4 molecules)
4
D-lactate Dehydrogenase
Molecule annotation
Chemicals (42 molecules)
1
5
2
4
3
4
4
10
5
8
6
11
* Click molecule labels to explore molecular sequence information.

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