3JY0: Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors

PDB ID: 3JY0Download
MMDB ID: 78042
PDB Deposition Date: 2009/9/21
Updated in MMDB: 2009/11
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 3JY0: monomeric; determined by author and by software (PISA)
Molecular Components in 3JY0
Label Count Molecule
Protein (1 molecule)
1
Proto-oncogene Serine/threonine-protein Kinase Pim-1
(Gene symbol: PIM1)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
8-chloro-2-{[(3S)-3-hydroxypyrrolidin-1-yl]methyl}[1]benzothieno[3,2-d]pyrimidin-4(3H)-one8-chloro-2-{[(3S)-3-hydroxypyrrolidin-1-yl]methyl}[1]benzothieno[3,2-d]pyrimidin-4(3H)-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303