3IRO: Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase complexed with NADPH and Q-8 antifolate

PDB ID: 3IRODownload
MMDB ID: 83613
PDB Deposition Date: 2009/8/24
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 2.8  Å
Source Organism:
Similar Structures:
Biological Unit for 3IRO: dimeric; determined by author and by software (PISA)
Molecular Components in 3IRO
Label Count Molecule
Proteins (2 molecules)
2
Bifunctional Dihydrofolate Reductase-thymidylate Synthase
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
2
5-[3-(3-fluorophenoxy)propoxy]quinazoline-2,4-diamine5-[3-(3-fluorophenoxy)propoxy]quinazoline-2,4-diamine
2
2
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
3
2
PHOSPHATE IONPHOSPHATE ION
4
6
ACETATE IONACETATE ION
5
2
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303