3I55: Co-crystal structure of Mycalamide A Bound to the Large Ribosomal Subunit

Citation:
Abstract
Structures have been obtained for the complexes that triacetyloleandomycin and mycalamide A form with the large ribosomal subunit of Haloarcula marismortui. Triacetyloleandomycin binds in the nascent peptide tunnel and inhibits the activity of ribosomes by blocking the growth of the nascent peptide chain. Mycalamide A binds to the E site and inhibits protein synthesis by occupying the space normally occupied by the CCA end of E-site-bound tRNAs.
PDB ID: 3I55Download
MMDB ID: 80654
PDB Deposition Date: 2009/7/3
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 3.11  Å
Source Organism:
Haloarcula marismortui ATCC 43049
Similar Structures:
Biological Unit for 3I55: 32-meric; determined by author and by software (PISA)
Molecular Components in 3I55
Label Count Molecule
Proteins (29 molecules)
1
50S Ribosomal Protein L2P(Gene symbol: RR_RS11185)
Molecule annotation
1
50S Ribosomal Protein L3P(Gene symbol: RR_RS11200)
Molecule annotation
1
50S Ribosomal Protein L4P(Gene symbol: RR_RS11195)
Molecule annotation
1
50S Ribosomal Protein L5P(Gene symbol: RR_RS11135)
Molecule annotation
1
50S Ribosomal Protein L6P(Gene symbol: RR_RS11120)
Molecule annotation
1
50S Ribosomal Protein L7ae(Gene symbol: RR_RS04485)
Molecule annotation
1
50S Ribosomal Protein L10e(Gene symbol: RR_RS10280)
Molecule annotation
1
50S Ribosomal Protein L10e(Gene symbol: RR_RS14520)
Molecule annotation
1
50S Ribosomal Protein L11p(Gene symbol: RR_RS10270)
Molecule annotation
1
50S Ribosomal Protein L13p(Gene symbol: RR_RS04320)
Molecule annotation
1
50S Ribosomal Protein L14p(Gene symbol: RR_RS11150)
Molecule annotation
1
50S Ribosomal Protein L15p(Gene symbol: RR_RS11090)
Molecule annotation
1
50S Ribosomal Protein L15e(Gene symbol: RR_RS13190)
Molecule annotation
1
50S Ribosomal Protein L18p(Gene symbol: RR_RS11105)
Molecule annotation
1
50S Ribosomal Protein L18e(Gene symbol: RR_RS04315)
Molecule annotation
1
50S Ribosomal Protein L19e(Gene symbol: RR_RS11110)
Molecule annotation
1
50S Ribosomal Protein L21e(Gene symbol: RR_RS05195)
Molecule annotation
1
50S Ribosomal Protein L22p(Gene symbol: RR_RS11175)
Molecule annotation
1
50S Ribosomal Protein L23p(Gene symbol: RR_RS11190)
Molecule annotation
1
50S Ribosomal Protein L24p(Gene symbol: RR_RS11145)
Molecule annotation
1
50S Ribosomal Protein L24e(Gene symbol: RR_RS04495)
Molecule annotation
1
50S Ribosomal Protein L29p(Gene symbol: RR_RS11165)
Molecule annotation
1
50S Ribosomal Protein L30p(Gene symbol: RR_RS11095)
Molecule annotation
1
50S Ribosomal Protein L31e(Gene symbol: RR_RS17815)
Molecule annotation
1
50S Ribosomal Protein L32e(Gene symbol: RR_RS11115)
Molecule annotation
1
50S Ribosomal Protein L37ae(Gene symbol: RR_RS11475)
Molecule annotation
1
50S Ribosomal Protein L37e
Molecule annotation
1
50S Ribosomal Protein L39e(Gene symbol: RR_RS17810)
Molecule annotation
1
50S Ribosomal Protein L44e(Gene symbol: RR_RS19595)
Molecule annotation
Nucleotides(3 molecules)
1
23S Ribosomal RNA
Molecule annotation
1
5S Ribosomal RNA
Molecule annotation
1
Dna/rna (5'-r(*cp*cp*(5aa)p*(2op)p*(po2)p*ap*cp*c)-3')
Molecule annotation
Chemicals (307 molecules)
1
1
Molecule information is not avaliable.
2
93
3
2
4
75
5
22
6
108
7
1
8
5
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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