3H9Z: Crystal structure of the IgE-Fc3-4 domains

The structure of immunoglobulin E (IgE)-Fc(3-4) has been solved in three new crystal forms, providing 13 snapshots of the Fc conformation and revealing a diverse range of open-closed motions among subunit chains and dimers. A more detailed analysis of the open-to-closed motion of IgE-Fc(3-4) was possible with so many structures, and the new structures allow a more thorough examination of the flexibility of IgE-Fc and its implications for receptor binding. The existence of a hydrophobic pocket at the elbow region of the Fc appears to be conformation dependent and suggests a means of regulating the IgE-Fc conformation (and potentially receptor binding) with small molecules.
PDB ID: 3H9ZDownload
MMDB ID: 76583
PDB Deposition Date: 2009/4/30
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 2.45  Å
Source Organism:
Similar Structures:
Biological Unit for 3H9Z: dimeric; determined by author and by software (PISA)
Molecular Components in 3H9Z
Label Count Molecule
Proteins (2 molecules)
IG Epsilon Chain C Region(Gene symbol: IGHE)
Molecule annotation
Chemicals (4 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB