3H0A: Crystal Structure Of Peroxisome Proliferator-activated Receptor Gamma (pparg) And Retinoic Acid Receptor Alpha (rxra) In Complex With 9-cis Retinoic Acid, Co-activator Peptide, And A Partial Agonist

PDB ID: 3H0ADownload
MMDB ID: 73200
PDB Deposition Date: 2009/4/8
Updated in MMDB: 2009/06
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 3H0A: tetrameric; determined by author and by software (PISA)
Molecular Components in 3H0A
Label Count Molecule
Proteins (4 molecules)
1
Retinoic Acid Receptor Rxr-alpha
(Gene symbol: RXRA)
Molecule annotation
1
Peroxisome Proliferator-activated Receptor Gamma
(Gene symbol: PPARG)
Molecule annotation
2
Nuclear Receptor Coactivator 1, Co-activator Peptide
(Gene symbol: NCOA1)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)ethenyl]benzoic Acid4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)ethenyl]benzoic Acid
2
1
[(4-{[2-(Pent-2-Yn-1-Yloxy)-4-{[4-(Trifluoromethyl)phenoxy]methyl}phenyl]sulfanyl}-5,6,7,8-Tetrahydronaphthalen-1-Yl)oxy]acetic Acid[(4-{[2-(Pent-2-Yn-1-Yloxy)-4-{[4-(Trifluoromethyl)phenoxy]methyl}phenyl]sulfanyl}-5,6,7,8-Tetrahydronaphthalen-1-Yl)oxy]acetic Acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303