3H0A: Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (PPARg) and Retinoic Acid Receptor Alpha (RXRa) in Complex with 9-cis Retinoic Acid, Co-activator Peptide, and a Partial Agonist

PDB ID: 3H0ADownload
MMDB ID: 73200
PDB Deposition Date: 2009/4/8
Updated in MMDB: 2009/06
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 3H0A: tetrameric; determined by author and by software (PISA)
Molecular Components in 3H0A
Label Count Molecule
Proteins (4 molecules)
1
Retinoic Acid Receptor Rxr-alpha
(Gene symbol: RXRA)
Molecule annotation
1
Peroxisome Proliferator-activated Receptor Gamma
(Gene symbol: PPARG)
Molecule annotation
2
Nuclear Receptor Coactivator 1, Co-activator Peptide
(Gene symbol: NCOA1)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid
2
1
[(4-{[2-(pent-2-yn-1-yloxy)-4-{[4-(trifluoromethyl)phenoxy]methyl}phenyl]sulfanyl}-5,6,7,8-tetrahydronaphthalen-1-yl)oxy]acetic acid[(4-{[2-(pent-2-yn-1-yloxy)-4-{[4-(trifluoromethyl)phenoxy]methyl}phenyl]sulfanyl}-5,6,7,8-tetrahydronaphthalen-1-yl)oxy]acetic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303