3GWX: Molecular Recognition Of Fatty Acids By Peroxisome Proliferator-activated Receptors

Citation:
Abstract
The peroxisome proliferator-activated receptors (PPARs) are nuclear receptors for fatty acids (FAs) that regulate glucose and lipid homeostasis. We report the crystal structure of the PPAR delta ligand-binding domain (LBD) bound to either the FA eicosapentaenoic acid (EPA) or the synthetic fibrate GW2433. The carboxylic acids of EPA and GW2433 interact directly with the activation function 2 (AF-2) helix. The hydrophobic tail of EPA adopts two distinct conformations within the large hydrophobic cavity. GW2433 occupies essentially the same space as EPA bound in both conformations. These structures provide molecular insight into the propensity for PPARs to interact with a variety of synthetic and natural compounds, including FAs that vary in both chain length and degree of saturation.
PDB ID: 3GWXDownload
MMDB ID: 13176
PDB Deposition Date: 1999/4/26
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 3GWX: dimeric; determined by author
Molecular Components in 3GWX
Label Count Molecule
Proteins (2 molecules)
2
Protein (Peroxisome Proliferator Activated Receptor (Ppar-delta))(Gene symbol: PPARD)
Molecule annotation
Chemicals (2 molecules)
1
2
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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