3GHV: Human dihydrofolate reductase Q35K/N64F double mutant inhibitor complex

PDB ID: 3GHVDownload
MMDB ID: 76849
PDB Deposition Date: 2009/3/4
Updated in MMDB: 2021/10
Experimental Method:
x-ray diffraction
Resolution: 1.3  Å
Source Organism:
Similar Structures:
Biological Unit for 3GHV: monomeric; determined by author and by software (PISA)
Molecular Components in 3GHV
Label Count Molecule
Protein (1 molecule)
1
Dihydrofolate Reductase
(Gene symbol: DHFR)
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
1
N-({4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]phenyl}carbonyl)-L-glutamic acidN-({4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]phenyl}carbonyl)-L-glutamic acid
2
1
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
3
1
GLYCEROLGLYCEROL
4
6
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303