3G75: Crystal Structure Of Staphylococcus Aureus Gyrase B Co-complexed With 4-methyl-5-[3-(methylsulfanyl)-1h-pyrazol-5-yl]-2-thiophen-2-yl-1,3- Thiazole Inhibitor

Citation:
Abstract
Bacterial DNA gyrase is an attractive target for the investigation of new antibacterial agents. Inhibitors of the GyrB subunit, which contains the ATP-binding site, are described in this communication. Novel, substituted 5-(1H-pyrazol-3-yl)thiazole compounds were identified as inhibitors of bacterial gyrase. Structure-guided optimization led to greater enzymatic potency and moderate antibacterial potency. Data are presented for the demonstration of selective enzyme inhibition of Escherichia coli GyrB over Staphylococcus aureus GyrB.
PDB ID: 3G75Download
MMDB ID: 79934
PDB Deposition Date: 2009/2/9
Updated in MMDB: 2013/07
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 3G75: monomeric; determined by author and by software (PISA)
Molecular Components in 3G75
Label Count Molecule
Protein (1 molecule)
1
DNA Gyrase Subunit B
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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