3FYK: Crystal structure of a benzthiophene lead bound to MAPKAP Kinase-2 (MK-2)

Citation:
Abstract
Optimization of kinase selectivity for a set of benzothiophene MK2 inhibitors provided analogs with potencies of less than 500 nM in a cell based assay. The selectivity of the inhibitors can be rationalized by examination of X-ray crystal structures of inhibitors bound to MK2.
PDB ID: 3FYKDownload
MMDB ID: 70715
PDB Deposition Date: 2009/1/22
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 3.5  Å
Source Organism:
Similar Structures:
Biological Unit for 3FYK: monomeric; determined by author
Molecular Components in 3FYK
Label Count Molecule
Protein (1 molecule)
1
MAP Kinase-activated Protein Kinase 2(Gene symbol: MAPKAPK2)
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

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