National Center for
3FV8: Jnk3 Bound To Piperazine Amide Inhibitor, Sr2774
Bioorg. Med. Chem. Lett. (2009) 19 p.3344-3347
A novel series of c-jun N-terminal kinase (JNK) inhibitors were designed and developed from a high-throughput-screening hit. Through the optimization of the piperazine amide 1, several potent compounds were discovered. The X-ray crystal structure of 4g showed a unique binding mode different from other well known JNK3 inhibitors.