3FV8: Jnk3 Bound To Piperazine Amide Inhibitor, Sr2774

Citation:
Abstract
A novel series of c-jun N-terminal kinase (JNK) inhibitors were designed and developed from a high-throughput-screening hit. Through the optimization of the piperazine amide 1, several potent compounds were discovered. The X-ray crystal structure of 4g showed a unique binding mode different from other well known JNK3 inhibitors.
PDB ID: 3FV8Download
MMDB ID: 70712
PDB Deposition Date: 2009/1/15
Updated in MMDB: 2017/08
Experimental Method:
x-ray diffraction
Resolution: 2.28  Å
Source Organism:
Similar Structures:
Biological Unit for 3FV8: monomeric; determined by author and by software (PISA)
Molecular Components in 3FV8
Label Count Molecule
Protein (1 molecule)
1
Mitogen-activated Protein Kinase 10(Gene symbol: MAPK10)
Molecule annotation
Chemicals (6 molecules)
1
1
2
5
* Click molecule labels to explore molecular sequence information.

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