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3FRJ:
Crystal Structure of 11b-Hydroxysteroid Dehydrogenase-1 (11b-HSD1) in Complex with Piperidyl Benzamide Inhibitor
PDB ID:
3FRJ
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MMDB ID:
73330
PDB Deposition Date:
2009/1/8
Updated in MMDB:
2021/10
Experimental Method:
x-ray diffraction
Resolution:
2.3 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 3FRJ: dimeric; determined by author
Molecular Components in 3FRJ
Label
Count
Molecule
Proteins (2 molecules)
A
B
2
Corticosteroid 11-beta-dehydrogenase, Isozyme 1
(Gene symbol:
HSD11B1
)
Chemicals and Non-standard biopolymers (3 molecules)
1
2
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2
1
N-{1-[(1-carbamoylcyclopropyl)methyl]piperidin-4-yl}-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303