3FOF: Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases

PDB ID: 3FOFDownload
MMDB ID: 69867
PDB Deposition Date: 2008/12/30
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 4  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 3FOF: octameric; determined by author and by software (PISA)
Molecular Components in 3FOF
Label Count Molecule
Proteins (4 molecules)
2
DNA Topoisomerase 4 Subunit a
Molecule annotation
2
DNA Topoisomerase 4 Subunit B
Molecule annotation
Nucleotides(4 molecules)
1
DNA (5'-d(p*ap*cp*cp*ap*ap*gp*gp*tp*cp*ap*tp*gp*ap*ap*t)-3')
Molecule annotation
1
DNA (5'-d(p*ap*gp*tp*cp*ap*tp*tp*cp*ap*tp*gp*ap*cp*cp*tp*tp*gp*gp*t)-3')
Molecule annotation
1
DNA (5'-d(p*cp*tp*gp*tp*tp*tp*tp*ap*cp*gp*tp*gp*cp*ap*t)-3')
Molecule annotation
1
DNA (5'-d(p*gp*ap*cp*tp*ap*tp*gp*cp*ap*cp*gp*tp*ap*ap*ap*ap*cp*ap*g)-3')
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303