3FDN: Structure-based drug design of novel Aurora kinase A inhibitors: Structure basis for potency and specificity

PDB ID: 3FDNDownload
MMDB ID: 76705
PDB Deposition Date: 2008/11/26
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 3FDN: monomeric; determined by author and by software (PISA)
Molecular Components in 3FDN
Label Count Molecule
Protein (1 molecule)
1
Serine/threonine-protein Kinase 6
(Gene symbol: AURKA)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-[3-(acetylamino)phenyl]-5-{(2E)-2-[(4-methoxyphenyl)methylidene]hydrazino}-3-methyl-1H-pyrazole-4-carboxamideN-[3-(acetylamino)phenyl]-5-{(2E)-2-[(4-methoxyphenyl)methylidene]hydrazino}-3-methyl-1H-pyrazole-4-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303