3FDM: Alpha/beta Foldamer In Complex With Bcl-xl

Get into the groove: The first high-resolution structure of a foldamer bound to a protein target is described (see picture; foldamer in sticks). The foldamer consists of alpha- and beta-amino acid residues and is bound to the anti-apoptotic protein Bcl-x(L). The overall binding mode and key interactions observed in the foldamer/Bcl-x(L) complex mimic those seen in complexes of Bcl-x(L) with natural alpha-peptide ligands. Additional contacts in the foldamer/Bcl-x(L) complex involving beta-amino acid residues appear to contribute to binding affinity.
PDB ID: 3FDMDownload
MMDB ID: 70137
PDB Deposition Date: 2008/11/26
Updated in MMDB: 2017/08
Experimental Method:
x-ray diffraction
Resolution: 2.26  Å
Source Organism:
synthetic construct
Similar Structures:
Biological Unit for 3FDM: tetrameric; determined by author and by software (PISA)
Molecular Components in 3FDM
Label Count Molecule
Proteins (4 molecules)
Apoptosis Regulator Bcl-x(Gene symbol: BCL2L1)
Molecule annotation
Alpha/beta-peptide Foldamer
Molecule annotation
Chemicals (11 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB