3F3U: Kinase Domain Of Csrc In Complex With Inhibitor Rl37 (Type Iii)

Targeting kinases outside the highly conserved ATP pocket is thought to be a promising strategy for overcoming bottlenecks in kinase inhibitor research, such as limited selectivity and drug resistance. Here we report the development and application of a direct binding assay to detect small molecules that stabilize the inactive conformation of the tyrosine kinase cSrc. Protein X-ray crystallography validated the assay results and confirmed an exclusively allosteric binding mode.
PDB ID: 3F3UDownload
MMDB ID: 69976
PDB Deposition Date: 2008/10/31
Updated in MMDB: 2012/10
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 3F3U: monomeric; determined by author and by software (PISA)
Molecular Components in 3F3U
Label Count Molecule
Protein (1 molecule)
Proto-oncogene Tyrosine-protein Kinase SRC(Gene symbol: SRC)
Molecule annotation
Chemicals (2 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB