3EIG: Crystal structure of a methotrexate-resistant mutant of human dihydrofolate reductase

PDB ID: 3EIGDownload
MMDB ID: 72890
PDB Deposition Date: 2008/9/15
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 1.7  Å
Source Organism:
Similar Structures:
Biological Unit for 3EIG: monomeric; determined by author and by software (PISA)
Molecular Components in 3EIG
Label Count Molecule
Protein (1 molecule)
1
Dihydrofolate Reductase
(Gene symbol: DHFR)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
1
METHOTREXATEMETHOTREXATE
2
8
SULFATE IONSULFATE ION
3
1
CADMIUM IONCADMIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303