3EID: Cdk2CYCLINA COMPLEXED WITH A PYRAZOLOPYRIDAZINE INHIBITOR

Citation:
Abstract
A novel series of pyrazolo[1,5-b]pyridazines have been synthesized and identified as cyclin dependant kinase inhibitors potentially useful for the treatment of solid tumors. Modification of the hinge-binding amine or the C(2)- and C(6)-substitutions on the pyrazolopyridazine core provided potent inhibitors of CDK4 and demonstrated enzyme selectivity against VEGFR-2 and GSK3beta.
PDB ID: 3EIDDownload
MMDB ID: 67507
PDB Deposition Date: 2008/9/15
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 3.15  Å
Source Organism:
Similar Structures:
Biological Unit for 3EID: dimeric; determined by author and by software (PISA)
Molecular Components in 3EID
Label Count Molecule
Proteins (2 molecules)
1
Cell Division Protein Kinase 2(Gene symbol: CDK2)
Molecule annotation
1
Cyclin-a2(Gene symbol: CCNA2)
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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