3EE8: Structure Of Ns1 Effector Domain

The nonstructural protein NS1A from influenza virus is a multifunctional virulence factor and a potent inhibitor of host immunity. It has two functional domains: an N-terminal 73-amino-acid RNA-binding domain and a C-terminal effector domain. Here, the crystallographic structure of the NS1A effector domain of influenza A/Udorn/72 virus is presented. Structure comparison with the NS1 effector domain from mouse-adapted influenza A/Puerto Rico/8/34 (PR8) virus strain reveals a similar monomer conformation but a different dimer interface. Further analysis and evaluation shows that the dimer interface observed in the structure of the PR8 NS1 effector domain is likely to be a crystallographic packing effect. A hypothetical model of the intact NS1 dimer is presented.
PDB ID: 3EE8Download
MMDB ID: 69001
PDB Deposition Date: 2008/9/4
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Source Organism:
Similar Structures:
Biological Unit for 3EE8: monomeric; determined by software (PISA)
Molecular Components in 3EE8
Label Count Molecule
Protein (1 molecule)
Non-structural Protein 1
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB