3E4U: Crystal Structure Of The Wild-Type Human Bcl6 BtbPOZ DOMAIN

Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2008) 64 p.1101-1104
BCL6 is a transcriptional repressor that is overexpressed in diffuse large B-cell lymphoma and follicular lymphoma. The N-terminal POZ domain of BCL6 interacts with transcriptional corepressors and targeting these associations is a promising therapeutic strategy. Previous structural studies of the BCL6 POZ domain have used a mutant form because of the low solubility of the wild-type recombinant protein. A method for the purification and crystallization of the wild-type BCL6 POZ domain is described and the crystal structure to 2.1 A resolution is reported. This will be relevant for the design of therapeutics that target BCL6 POZ-domain interaction interfaces.
PDB ID: 3E4UDownload
MMDB ID: 68420
PDB Deposition Date: 2008/8/12
Updated in MMDB: 2008/12
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 3E4U: dimeric; determined by author and by software (PISA)
Molecular Components in 3E4U
Label Count Molecule
Proteins (2 molecules)
B-cell Lymphoma 6 Protein(Gene symbol: BCL6)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB