3DCT: Fxr With Src1 And Gw4064

Starting from the known FXR agonist GW 4064 1a, a series of stilbene replacements were prepared. The 6-substituted 1-naphthoic acid 1b was an equipotent FXR agonist with improved developability parameters relative to 1a. Analog 1b also reduced the severity of cholestasis in the ANIT acute cholestatic rat model.
PDB ID: 3DCTDownload
MMDB ID: 66041
PDB Deposition Date: 2008/6/4
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Homo sapiens
Similar Structures:
Biological Unit for 3DCT: dimeric; determined by software (PISA)
Molecular Components in 3DCT
Label Count Molecule
Proteins (2 molecules)
Bile Acid Receptor(Gene symbol: NR1H4)
Molecule annotation
Nuclear Receptor Coactivator 1(Gene symbol: NCOA1)
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

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