National Center for
3CID: Structure Of Bace Bound To Sch726222
Bioorg. Med. Chem. Lett. (2008) 18 p.3236-3241
Guided by structure-based design, we synthesized two novel series of potent inhibitors of BACE1 and generated extensive SAR around both the prime and non-prime side binding pockets. The key feature of both series is a cyclic amine motif specifically crafted to achieve interactions with both the flap and with the S2' pocket.