National Center for
3CGH: Crystal Structure Of A Susd Homolog (bt_3984) From Bacteroides Thetaiotaomicron Vpi-5482 At 1.70 A Resolution
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2010) 66 p.1274-1280
The crystal structure of the Bacteroides thetaiotaomicron protein BT_3984 was determined to a resolution of 1.7 A and was the first structure to be determined from the extensive SusD family of polysaccharide-binding proteins. SusD is an essential component of the sus operon that defines the paradigm for glycan utilization in dominant members of the human gut microbiota. Structural analysis of BT_3984 revealed an N-terminal region containing several tetratricopeptide repeats (TPRs), while the signature C-terminal region is less structured and contains extensive loop regions. Sequence and structure analysis of BT_3984 suggests the presence of binding interfaces for other proteins from the polysaccharide-utilization complex.