3BT2: Structure Of Urokinase Receptor, Urokinase And Vitronectin Complex

Citation:
Abstract
The urokinase receptor (uPAR) can recognize several ligands. The structural basis for this multiple ligand recognition by uPAR is unknown. This study reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor. These results provide a structural understanding of one receptor binding to two ligands.
PDB ID: 3BT2Download
MMDB ID: 63296
PDB Deposition Date: 2007/12/27
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Mus musculus
Similar Structures:
Biological Unit for 3BT2: pentameric; determined by author
Molecular Components in 3BT2
Label Count Molecule
Proteins (5 molecules)
1
Urokinase-type Plasminogen Activator(Gene symbol: PLAU)
Molecule annotation
1
Vitronectin(Gene symbol: VTN)
Molecule annotation
1
Anti-upar Antibody, Light Chain
Molecule annotation
1
Anti-upar Antibody, Heavy Chain
Molecule annotation
1
Urokinase Plasminogen Activator Surface Receptor(Gene symbol: PLAUR)
Molecule annotation
Chemicals (5 molecules)
1
5
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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