3BP5: Crystal Structure Of The Mouse Pd-1 And Pd-l2 Complex

Citation:
Abstract
Programmed death-1 (PD-1) is a member of the CD28/B7 superfamily that delivers negative signals upon interaction with its two ligands, PD-L1 or PD-L2. The high-resolution crystal structure of the complex formed by the complete ectodomains of murine PD-1 and PD-L2 revealed a 1:1 receptor:ligand stoichiometry and displayed a binding interface and overall molecular organization distinct from that observed in the CTLA-4/B7 inhibitory complexes. Furthermore, our structure also provides insights into the association between PD-1 and PD-L1 and highlights differences in the interfaces formed by the two PD-1 ligands (PD-Ls) Mutagenesis studies confirmed the details of the proposed PD-1/PD-L binding interfaces and allowed for the design of a mutant PD-1 receptor with enhanced affinity. These studies define spatial and organizational constraints that control the localization and signaling of PD-1/PD-L complexes within the immunological synapse and provide a basis for manipulating the PD-1 pathways for immunotherapy.
PDB ID: 3BP5Download
MMDB ID: 65478
PDB Deposition Date: 2007/12/18
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit for 3BP5: dimeric; determined by author and by software (PISA)
Molecular Components in 3BP5
Label Count Molecule
Proteins (2 molecules)
1
Programmed Cell Death Protein 1(Gene symbol: Pdcd1)
Molecule annotation
1
Programmed Cell Death 1 Ligand 2(Gene symbol: Pdcd1lg2)
Molecule annotation
Chemicals (2 molecules)
1
1
2
1
Molecule information is not avaliable.
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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