3BEA: Cfms Tyrosine Kinase (tie2 Kid) In Complex With A Pyrimidinopyridone Inhibitor

Citation:
Abstract
A series of pyrimidinopyridones has been designed, synthesized and shown to be potent and selective inhibitors of the FMS tyrosine kinase. Introduction of an amide substituent at the 6-position of the pyridone core resulted in a significant potency increase. Compound 24 effectively inhibited in vivo LPS-induced TNF in mice greater than 80%.
PDB ID: 3BEADownload
MMDB ID: 65475
PDB Deposition Date: 2007/11/16
Updated in MMDB: 2017/08
Experimental Method:
x-ray diffraction
Resolution: 2.02  Å
Source Organism:
Similar Structures:
Biological Unit for 3BEA: monomeric; determined by author and by software (PISA)
Molecular Components in 3BEA
Label Count Molecule
Protein (1 molecule)
1
Macrophage Colony-stimulating Factor 1 Receptor
Molecule annotation
Chemicals (4 molecules)
1
3
2
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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