3B3X: Crystal Structure Of Class A Beta-Lactamase Of Bacillus Licheniformis Bs3 With Aminocitrate

The title compound 4 has been prepared in four steps from ethylglycinate in 63% overall yield. This amino analog of citric acid has been co-crystallized with the class A beta-lactamase BS3 of Bacillus licheniformis and the structure of the complex fully analyzed by X-ray diffraction. Tris-ethyl aminocitrate 3 and the free tris-acid 4 have been tested against a member beta-lactamase from all distinct subgroups. They are novel inhibitors of class A beta-lactamases, still modest but more potent than citrate and isocitrate.
PDB ID: 3B3XDownload
MMDB ID: 60725
PDB Deposition Date: 2007/10/23
Updated in MMDB: 2010/12
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 3B3X: dimeric; determined by author
Molecular Components in 3B3X
Label Count Molecule
Proteins (2 molecules)
Molecule annotation
Chemicals (2 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB