3AZ1: Crystal Structure Analysis Of Vitamin D Receptor

Citation:
Abstract
Novel vitamin D(3) analogs with carboxylic acid were explored, focusing on a nonsecosteroidal analog, LG190178, with a bisphenyl skeleton. From X-ray analysis of these analogs with vitamin D receptor (VDR), the carboxyl groups had very unique hydrogen bonding interactions in VDR and mimicked 1alpha-hydroxy group and/or 3beta-hydroxy group of 1alpha,25-dihydroxyvitamin D(3). A highly potent analog, 6a, with good in vitro activity and pharmacokinetic profiles was identified from an SAR study. Compound 6a showed significant prevention of bone loss in a rat osteoporosis model by oral administration.
PDB ID: 3AZ1Download
MMDB ID: 94722
PDB Deposition Date: 2011/5/20
Updated in MMDB: 2011/11
Experimental Method:
x-ray diffraction
Resolution: 1.5  Å
Source Organism:
Similar Structures:
Biological Unit for 3AZ1: monomeric; determined by author and by software (PISA)
Molecular Components in 3AZ1
Label Count Molecule
Protein (1 molecule)
1
Vitamin D3 Receptor(Gene symbol: VDR)
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

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