3AUN: Crystal Structure Of The Rat Vitamin D Receptor Ligand Binding Domain Complexed With Yr335 And A Synthetic Peptide Containing The Nr2 Box Of Drip 205

Citation:
Abstract
We designed and synthesized nonsecosteroidal vitamin D receptor (VDR) ligands that formed H-bonds with six amino acid residues (Tyr143, Ser233, Arg270, Ser274, His301 and His393) of the VDR ligand-binding domain. The ligand YR335 exhibited potent transcriptional activity, which was comparable to those of 1alpha,25-dihydroxyvitamin D(3) and YR301. The crystal structure of the complex formed between YR335 and the VDR ligand-binding domain was solved, which revealed that YR335 formed H-bonds with the six amino acid residues mentioned above.
PDB ID: 3AUNDownload
MMDB ID: 97208
PDB Deposition Date: 2011/2/10
Updated in MMDB: 2017/09
Experimental Method:
x-ray diffraction
Resolution: 1.81  Å
Source Organism:
synthetic construct
Similar Structures:
Biological Unit for 3AUN: dimeric; determined by author and by software (PISA)
Molecular Components in 3AUN
Label Count Molecule
Proteins (2 molecules)
1
Vitamin D3 Receptor(Gene symbol: Vdr)
Molecule annotation
1
Drip 205 NR2 BOX Peptide(Gene symbol: MED1)
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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