3ATY: Crystal Structure Of Tcoye

Old yellow enzyme (OYE) is an NADPH oxidoreductase capable of reducing a variety of compounds. It contains flavin mononucleotide (FMN) as a prosthetic group. A ternary complex structure of OYE from Trypanosoma cruzi (TcOYE) with FMN and one of the substrates, p-hydroxybenzaldehyde, shows a striking movement around the active site upon binding of the substrate. From a structural comparison of other OYE complexed with 12-oxophytodienoate, we have constructed a complex structure with another substrate, prostaglandin H(2) (PGH(2)), to provide a proposed stereoselective reaction mechanism for the reduction of PGH(2) to prostaglandin F(2alpha) by TcOYE.
PDB ID: 3ATYDownload
MMDB ID: 90273
PDB Deposition Date: 2011/1/26
Updated in MMDB: 2011/05
Experimental Method:
x-ray diffraction
Resolution: 1.7  Å
Source Organism:
Similar Structures:
Biological Unit for 3ATY: monomeric; determined by author and by software (PISA)
Molecular Components in 3ATY
Label Count Molecule
Protein (1 molecule)
Prostaglandin F2A Synthase
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

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