2Z9K: Complex Structure Of Sars-Cov 3c-Like Protease With Jmf1600

Five active metal-conjugated inhibitors (PMA, TDT, EPDTC, JMF1586 and JMF1600) bound with the 3C-like protease of severe acute respiratory syndrome (SARS)-associated coronavirus were analyzed crystallographically. The complex structures reveal two major inhibition modes: Hg(2+)-PMA is coordinated to C(44), M(49) and Y(54) with a square planar geometry at the S3 pocket, whereas each Zn(2+) of the four zinc-inhibitors is tetrahedrally coordinated to the H(41)-C(145) catalytic dyad. For anti-SARS drug design, this Zn(2+)-centered coordination pattern would serve as a starting platform for inhibitor optimization.
PDB ID: 2Z9KDownload
MMDB ID: 61558
PDB Deposition Date: 2007/9/20
Updated in MMDB: 2007/12
Experimental Method:
x-ray diffraction
Resolution: 1.85  Å
Source Organism:
Similar Structures:
Biological Unit for 2Z9K: dimeric; determined by author and by software (PISA)
Molecular Components in 2Z9K
Label Count Molecule
Proteins (2 molecules)
3c-like Proteinase
Molecule annotation
Chemicals (6 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB