2Z8M: Structural Basis For The Catalytic Mechanism Of Phosphothreonine Lyase

Salmonella SpvC belongs to a new enzyme family designated phosphothreonine lyases that irreversibly inactivate mitogen-activated protein kinases. The crystal structure of SpvC reported here reveals that the two phosphorylated residues in the substrate peptide predominantly mediate its recognition by SpvC. Substrate-induced conformational changes in SpvC sequester the phosphothreonine in a completely solvent-free environment, preventing the hydrolysis of the phosphate group and facilitating the elimination reaction.
PDB ID: 2Z8MDownload
MMDB ID: 61411
PDB Deposition Date: 2007/9/7
Updated in MMDB: 2007/12
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 2Z8M: monomeric; determined by author
Molecular Components in 2Z8M
Label Count Molecule
Protein (1 molecule)
27.5 KDA Virulence Protein(Gene symbol: spvC)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB