2YHW: High-resolution crystal structures of N-Acetylmannosamine kinase: Insights about substrate specificity, activity and inhibitor modelling

PDB ID: 2YHWDownload
MMDB ID: 97552
PDB Deposition Date: 2011/5/8
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 1.64  Å
Source Organism:
Similar Structures:
Biological Unit for 2YHW: dimeric; determined by author and by software (PISA)
Molecular Components in 2YHW
Label Count Molecule
Proteins (2 molecules)
2
Bifunctional Udp-n-acetylglucosamine 2-epimerase/n-acetylmannosamine Kinase
(Gene symbol: GNE)
Molecule annotation
Chemicals and Non-standard biopolymers (24 molecules)
1
2
2-acetamido-2-deoxy-alpha-D-mannopyranose2-acetamido-2-deoxy-alpha-D-mannopyranose
2
2
ZINC IONZINC ION
3
2
NONAETHYLENE GLYCOLNONAETHYLENE GLYCOL
4
8
1,2-ETHANEDIOL1,2-ETHANEDIOL
5
2
CALCIUM IONCALCIUM ION
6
4
TRIETHYLENE GLYCOLTRIETHYLENE GLYCOL
7
2
ACETATE IONACETATE ION
8
2
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303