2YFX: Structure of L1196M Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib

PDB ID: 2YFXDownload
MMDB ID: 90268
PDB Deposition Date: 2011/4/8
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 1.7  Å
Source Organism:
Similar Structures:
Biological Unit for 2YFX: monomeric; determined by author and by software (PISA)
Molecular Components in 2YFX
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase Receptor
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303