2Y6D: The Discovery of MMP7 Inhibitors Exploiting a Novel Selectivity Trigger

PDB ID: 2Y6DDownload
MMDB ID: 90266
PDB Deposition Date: 2011/1/20
Updated in MMDB: 2024/05
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 2Y6D: tetrameric; determined by software (PISA)
Molecular Components in 2Y6D
Label Count Molecule
Proteins (4 molecules)
4
Matrilysin
(Gene symbol: MMP7)
Molecule annotation
Chemicals and Non-standard biopolymers (28 molecules)
1
8
CALCIUM IONCALCIUM ION
2
8
ZINC IONZINC ION
3
8
SULFATE IONSULFATE ION
4
4
N-[(2S)-1-[4-(5-BROMOPYRIDIN-2-YL)PIPERAZIN-1-YL]SULFONYL-5-PYRIMIDIN-2-YL-PENTAN-2-YL]-N-HYDROXY-METHANAMIDEN-[(2S)-1-[4-(5-BROMOPYRIDIN-2-YL)PIPERAZIN-1-YL]SULFONYL-5-PYRIMIDIN-2-YL-PENTAN-2-YL]-N-HYDROXY-METHANAMIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303