2Y66: New 5-Benzylidenethiazolidine-4-one Inhibitors of Bacterial MurD Ligase: Design, Synthesis, Crystal Structures, and Biological Evaluation

PDB ID: 2Y66Download
MMDB ID: 94391
PDB Deposition Date: 2011/1/20
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 1.49  Å
Source Organism:
Similar Structures:
Biological Unit for 2Y66: monomeric; determined by author and by software (PISA)
Molecular Components in 2Y66
Label Count Molecule
Protein (1 molecule)
1
Udp-n-acetylmuramoylalanine--d-glutamate Ligase
(Gene symbol: murD)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
(2R)-2-[[3-[[3-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]methyl]phenyl]carbonylamino]pentanedioic acid(2R)-2-[[3-[[3-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]methyl]phenyl]carbonylamino]pentanedioic acid
2
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
3
1
SULFATE IONSULFATE ION
4
1
SULFITE IONSULFITE ION
5
1
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303