National Center for
2Y5K: Orally Active Aminopyridines As Inhibitors Of Tetrameric Fructose 1,6-Bisphosphatase
Bioorg. Med. Chem. Lett. (2011) 21 p.3237-3242
A novel sulfonylureido pyridine series exemplified by compound 19 yielded potent inhibitors of FBPase showing significant glucose reduction and modest glycogen lowering in the acute db/db mouse model for Type-2 diabetes. Our inhibitors occupy the allosteric binding site and also extend into the dyad interface region of tetrameric FBPase.