2Y5K: Orally Active Aminopyridines As Inhibitors Of Tetrameric Fructose 1,6-Bisphosphatase

A novel sulfonylureido pyridine series exemplified by compound 19 yielded potent inhibitors of FBPase showing significant glucose reduction and modest glycogen lowering in the acute db/db mouse model for Type-2 diabetes. Our inhibitors occupy the allosteric binding site and also extend into the dyad interface region of tetrameric FBPase.
PDB ID: 2Y5KDownload
MMDB ID: 90560
PDB Deposition Date: 2011/1/14
Updated in MMDB: 2011/10
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 2Y5K: tetrameric; determined by author and by software (PISA)
Molecular Components in 2Y5K
Label Count Molecule
Proteins (4 molecules)
Fructose-1,6-bisphosphatase 1(Gene symbol: FBP1)
Molecule annotation
Chemicals (4 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB