National Center for
2Y3Y: Holo-Ni(Ii) Hpnikr Is A Symmetric Tetramer Containing Four Canonic Square-Planar Ni(Ii) Ions At Physiological Ph
Holo-Ni(2+)Helicobacter pylori NikR contains four square-planar nickel-binding sites at physiological pH
Dalton Trans (2011) 40 p.7831-7833
The crystal structure of Helicobacter pylori holo-NikR, a Ni(2+)-dependent transcription factor, determined at pH 7.3, shows four square-planar nickel-binding sites, involving one cysteinate and three histidine ligands. This observation reconciles previous inconsistencies among calorimetric data, structural information at non-physiological pH, and computational studies.