2XYW: Novel Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (PPAR) gamma-delta Agonists with High Potency and In-vivo Efficacy

PDB ID: 2XYWDownload
MMDB ID: 88774
PDB Deposition Date: 2010/11/19
Updated in MMDB: 2024/05
Experimental Method:
x-ray diffraction
Resolution: 3.14  Å
Source Organism:
Similar Structures:
Biological Unit for 2XYW: monomeric; determined by author and by software (PISA)
Molecular Components in 2XYW
Label Count Molecule
Protein (1 molecule)
1
Peroxisome Proliferator-activated Receptor Delta
(Gene symbol: PPARD)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
3-CHLORO-6-FLUORO-N-[2-[4-[(5-PROPAN-2-YL-1,3,4-THIADIAZOL-2-YL)SULFAMOYL]PHENYL]ETHYL]-1-BENZOTHIOPHENE-2-CARBOXAMIDE3-CHLORO-6-FLUORO-N-[2-[4-[(5-PROPAN-2-YL-1,3,4-THIADIAZOL-2-YL)SULFAMOYL]PHENYL]ETHYL]-1-BENZOTHIOPHENE-2-CARBOXAMIDE
2
1
octyl beta-D-glucopyranosideoctyl beta-D-glucopyranoside
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303