2XXH: Crystal structure of 1-(4-(2-oxo-2-(1-pyrrolidinyl)ethyl)phenyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 1.5A resolution

PDB ID: 2XXHDownload
MMDB ID: 89642
PDB Deposition Date: 2010/11/10
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 1.5  Å
Source Organism:
Similar Structures:
Biological Unit for 2XXH: dimeric; determined by author and by software (PISA)
Molecular Components in 2XXH
Label Count Molecule
Proteins (2 molecules)
2
Glutamate Receptor 2
(Gene symbol: Gria2)
Molecule annotation
Chemicals and Non-standard biopolymers (11 molecules)
1
2
GLUTAMIC ACIDGLUTAMIC ACID
2
1
1-{4-[2-OXO-2-(1-PYRROLIDINYL)ETHYL]PHENYL}-3-( TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOLE1-{4-[2-OXO-2-(1-PYRROLIDINYL)ETHYL]PHENYL}-3-( TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOLE
3
2
SULFATE IONSULFATE ION
4
6
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303