National Center for
2XRD: Structure Of The N-Terminal Four Domains Of The Complement Regulator Rat Crry
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011) 67 p.739-743
Complement receptor 1-related protein Y (CrrY) is an important cell-surface regulator of complement that is unique to rodent species. The structure of rat CrrY domains 1-4 has been determined in two distinct crystal forms and reveals a 70 degrees bend between domains 3 and 4. Comparisons of this structure with those of other complement regulators suggests that rearrangement of this interface may occur on forming the regulatory complex with C3b.