2XPC: Second-generation sulfonamide inhibitors of MurD: Activity optimisation with conformationally rigid analogues of D-glutamic acid

PDB ID: 2XPCDownload
MMDB ID: 90553
PDB Deposition Date: 2010/8/26
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 1.49  Å
Source Organism:
Similar Structures:
Biological Unit for 2XPC: monomeric; determined by author and by software (PISA)
Molecular Components in 2XPC
Label Count Molecule
Protein (1 molecule)
1
Udp-n-acetylmuramoylalanine--d-glutamate Ligase
(Gene symbol: murD)
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
1
(1R,3R,4S)-4-[({6-[(4-CYANO-2-FLUOROBENZYL)OXY]NAPHTHALEN-2-YL}SULFONYL)AMINO]CYCLOHEXANE-1,3-DICARBOXYLIC ACID(1R,3R,4S)-4-[({6-[(4-CYANO-2-FLUOROBENZYL)OXY]NAPHTHALEN-2-YL}SULFONYL)AMINO]CYCLOHEXANE-1,3-DICARBOXYLIC ACID
2
3
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
3
4
SULFATE IONSULFATE ION
4
1
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303