2XC4: Factor Xa In Complex With A Pyrrolidine-3,4-dicarboxylic Acid Inhibitor

Citation:
Abstract
A series of (3R,4R)-pyrrolidine-3,4-dicarboxylic acid amides was investigated with respect to their factor Xa inhibitory activity, selectivity, pharmacokinetic properties, and ex vivo antithrombotic activity. The clinical candidate from this series, R1663, exhibits excellent selectivity against a panel of serine proteases and good pharmacokinetic properties in rats and monkeys. A Phase I clinical study with R1663 has been finalized.
PDB ID: 2XC4Download
MMDB ID: 83783
PDB Deposition Date: 2010/4/16
Updated in MMDB: 2010/08
Experimental Method:
x-ray diffraction
Resolution: 1.67  Å
Source Organism:
Similar Structures:
Biological Unit for 2XC4: dimeric; determined by author and by software (PISA)
Molecular Components in 2XC4
Label Count Molecule
Proteins (2 molecules)
1
Activated Factor XA Heavy Chain(Gene symbol: F10)
Molecule annotation
1
Factor X Light Chain(Gene symbol: F10)
Molecule annotation
Chemicals (3 molecules)
1
1
2
1
3
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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