2X4Y: Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1

Trimethylation of Lys36 in histone H3 (H3K36me3) coordinates events associated with the elongation phase of transcription and is also emerging as an important epigenetic regulator of cell growth and differentiation. We have identified the PWWP domain of bromo and plant homeodomain (PHD) finger-containing protein 1 (BRPF1) as a H3K36me3 binding module and have determined the structure of this domain in complex with an H3K36me3-derived peptide.
PDB ID: 2X4YDownload
MMDB ID: 81503
PDB Deposition Date: 2010/2/2
Updated in MMDB: 2012/09
Experimental Method:
x-ray diffraction
Resolution: 1.7  Å
Source Organism:
Homo sapiens
Similar Structures:
Biological Unit for 2X4Y: dimeric; determined by author and by software (PISA)
Molecular Components in 2X4Y
Label Count Molecule
Proteins (2 molecules)
Peregrin(Gene symbol: BRPF1)
Molecule annotation
Histone H3.2(Gene symbol: HIST2H3C)
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

Citing MMDB