2X4G: Crystal structure of PA4631, a nucleoside-diphosphate-sugar epimerase from Pseudomonas aeruginosa

The Scottish Structural Proteomics Facility was funded to develop a laboratory scale approach to high throughput structure determination. The effort was successful in that over 40 structures were determined. These structures and the methods harnessed to obtain them are reported here. This report reflects on the value of automation but also on the continued requirement for a high degree of scientific and technical expertise. The efficiency of the process poses challenges to the current paradigm of structural analysis and publication. In the 5 year period we published ten peer-reviewed papers reporting structural data arising from the pipeline. Nevertheless, the number of structures solved exceeded our ability to analyse and publish each new finding. By reporting the experimental details and depositing the structures we hope to maximize the impact of the project by allowing others to follow up the relevant biology.
PDB ID: 2X4GDownload
MMDB ID: 83420
PDB Deposition Date: 2010/1/30
Updated in MMDB: 2010/07
Experimental Method:
x-ray diffraction
Resolution: 2.65  Å
Source Organism:
Similar Structures:
Biological Unit for 2X4G: dimeric; determined by author and by software (PISA)
Molecular Components in 2X4G
Label Count Molecule
Proteins (2 molecules)
Nucleoside-diphosphate-sugar Epimerase
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB