2WZ0: L38v Sod1 Mutant Complexed With Aniline

Citation:
Abstract
Dominant inheritance of point mutations in CuZn superoxide dismutase (SOD1) is the best characterized subset of familial amyotrophic lateral sclerosis (FALS) and accounts for some 20% of the known familial cases. We report the discovery and visualization via cocrystallography of two ligand-binding pockets in human SOD1 and its pathogenic mutants that have opened up the real possibility of undertaking lead compound discovery using a fragment-based approach for therapeutic purposes for SOD1 associated motor neuron disease.
PDB ID: 2WZ0Download
MMDB ID: 87086
PDB Deposition Date: 2009/11/20
Updated in MMDB: 2010/12
Experimental Method:
x-ray diffraction
Resolution: 1.72  Å
Source Organism:
Similar Structures:
Biological Unit for 2WZ0: dimeric; determined by author and by software (PISA)
Molecular Components in 2WZ0
Label Count Molecule
Proteins (2 molecules)
2
Superoxide Dismutase [cu-zn](Gene symbol: SOD1)
Molecule annotation
Chemicals (11 molecules)
1
2
2
3
3
2
4
2
5
1
6
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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