2WHI: Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with a purine analogue inhibitor and L-methionine-S- sulfoximine phosphate

PDB ID: 2WHIDownload
MMDB ID: 76374
PDB Deposition Date: 2009/5/5
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 2WHI: dodecameric; determined by author and by software (PISA)
Molecular Components in 2WHI
Label Count Molecule
Proteins (12 molecules)
12
Glutamine Synthetase 1
Molecule annotation
Chemicals and Non-standard biopolymers (96 molecules)
1
12
1-(3,4-dichlorobenzyl)-3,7-dimethyl-8-morpholin-4-yl-3,7-dihydro-1H-purine-2,6-dione1-(3,4-dichlorobenzyl)-3,7-dimethyl-8-morpholin-4-yl-3,7-dihydro-1H-purine-2,6-dione
2
36
MAGNESIUM IONMAGNESIUM ION
3
12
L-METHIONINE-S-SULFOXIMINE PHOSPHATEL-METHIONINE-S-SULFOXIMINE PHOSPHATE
4
12
PHOSPHATE IONPHOSPHATE ION
5
12
CHLORIDE IONCHLORIDE ION
6
12
PENTAETHYLENE GLYCOLPENTAETHYLENE GLYCOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303